Nanoencapsulation of the omega-3 EPA:DHA 6:1 formulation enhances and sustains NO-mediated endothelium-dependent relaxations in coronary artery rings and NO formation in endothelial cells

The eicosapentaenoic acid (EPA) and docosahexaenoic (DHA) formulation with a ratio of 6:1 is potent stimulator the endothelial formation nitric oxide (NO). aim study was to investigate whether nanoencapsulation EPA:DHA followed by coating gum increases its biological activity. Vascular reactivity assessed using porcine coronary artery rings, NO in cultured cells (ECs) DAF-FM indirectly platelet aggregation studies. Coated nanoparticles induced sustained relaxations rings that were greater than those without endothelium, more pronounced native form. Treatment ECs coated caused enhanced their anti-aggregatory effects. Thus, an attractive strategy enhance beneficial effect at vascular endothelium.